Tag "publications"

An international team, including researchers from HSE University, has created the first comprehensive map of quadruplexes—unstable DNA structures involved in gene regulation. For the first time, scientists have shown that these structures function in pairs: one is located in a DNA region that initiates gene transcription, while the other lies in a nearby region that enhances this process. In healthy tissues, quadruplexes regulate tissue-specific genes, whereas in cancerous tissues they influence genes responsible for cell growth and division. These findings may contribute to the development of new anticancer drugs that target quadruplexes. The study has been published in Nucleic Acids Research.

Mathematician Ivan Remizov from HSE University–Nizhny Novgorod and the Institute for Information Transmission Problems of the Russian Academy of Sciences has made a conceptual breakthrough in the theory of differential equations. He has derived a universal formula for solving problems that had been considered unsolvable in quadratures for more than 190 years. This result fundamentally reshapes one of the oldest areas of mathematics and has potential to have important implications for fundamental physics and economics. The paper has been published in Vladikavkaz Mathematical Journal.

Valeria Vinogradova, a researcher at HSE University, together with British colleagues, studied how language proficiency affects cognitive processing in deaf adults. The study showed that higher language proficiency—regardless of whether the language is signed or spoken—is associated with higher activity and stronger functional connectivity within the brain network responsible for cognitive task performance. The findings have been published in Cerebral Cortex.

Scientists at the HSE AI Research Centre have developed a novel approach to determining robustness in deep learning models. Their method works eight times faster than an exhaustive model search and significantly reduces the need for manual verification. It can be applied to particle physics problems using neural networks of various architectures. The study has been published in IEEE Access.

Institute for Statistical Studies and Economics of Knowledge has analyzed the key statements of Brazil’s plan for artificial intelligence (AI) development approved by government, which envisages intensifying of research and training highly qualified personnel as well as AI technology implementation expanding in main industries.

An international team, including researchers from HSE University, examined an unusual SARS-CoV-2 sample obtained from an HIV-positive patient. Genetic analysis revealed multiple mutations and showed that the virus had been evolving inside the patient’s body for two years. This finding supports the theory that the virus can persist in individuals for years, gradually accumulate mutations, and eventually spill back into the population. The study's findings have been published in Frontiers in Cellular and Infection Microbiology.

Scientists at the HSE Centre for Language and Brain have demonstrated a more accurate way to identify the boundaries of language regions in the brain. They used magnetoencephalography (MEG) together with a sentence-completion task, which activates language areas and reveals their functioning in real time. This approach can help clinicians plan surgeries more effectively and improve diagnostic accuracy in cases where fMRI is not the optimal method. The study has been published in the European Journal of Neuroscience.

A team of researchers from Russia and the United Kingdom has, for the first time, provided a detailed account of the emergence and evolution of the Russian Sign Language (RSL) interpreter training system. This large-scale study spans from the 19^th century to the present day, revealing both the achievements and challenges faced by the professional community. Results have been published in The Routledge Handbook of Sign Language Translation and Interpreting.

Researchers at the HSE AI Research Centre have developed an AI model that opens up new possibilities for the diagnosis and treatment of serious diseases, including brain cancer and neurodegenerative disorders. Using artificial intelligence, the team studied G-quadruplexes—structures that play a crucial role in cellular function and in the development of organs and tissues. The findings have been published in Scientific Reports.

An international team including researchers from HSE MIEM has developed a catalyst that enables fast and low-cost hydrogen production from water. To achieve this, the scientists synthesised nanoparticles of a complex oxide containing six metals and anchored them onto various substrates. The catalyst supported on reduced graphene layers proved to be nearly three times more efficient than the same oxide without a substrate. This development could significantly reduce the cost of hydrogen production and accelerate the transition to green energy. The study has been published in ACS Applied Energy Materials. The work was carried out under a grant from the Russian Science Foundation.