HSE Development Programme until 2030

Scientists at HSE MIEM, in collaboration with colleagues from China, have developed a method to improve the durability of perovskite solar cells by addressing iodine loss from the material. The researchers introduced quaternary ammonium molecules into the perovskite structure; these molecules form strong electrostatic pairs with iodine ions, effectively anchoring them within the crystal lattice. As a result, the solar cells retain more than 92% of their power after a thousand hours of operation at 85°C. The study has been published in Advanced Energy Materials.

An international team, including researchers from HSE University, has created the first comprehensive map of quadruplexes—unstable DNA structures involved in gene regulation. For the first time, scientists have shown that these structures function in pairs: one is located in a DNA region that initiates gene transcription, while the other lies in a nearby region that enhances this process. In healthy tissues, quadruplexes regulate tissue-specific genes, whereas in cancerous tissues they influence genes responsible for cell growth and division. These findings may contribute to the development of new anticancer drugs that target quadruplexes. The study has been published in Nucleic Acids Research.

The HSE Graduate School of Business and the Tsinghua University School of Economics and Management (Tsinghua SEM) have signed a cooperation and exchange agreement aimed at developing joint education and research programs and strengthening academic dialogue between Russia and China.

Scientists at the HSE AI Research Centre have developed a novel approach to determining robustness in deep learning models. Their method works eight times faster than an exhaustive model search and significantly reduces the need for manual verification. It can be applied to particle physics problems using neural networks of various architectures. The study has been published in IEEE Access.

Eating habits can be shaped not only by the authority of medical experts but also through ordinary conversations among friends. Researchers at HSE University have shown that advice from peers to reduce sugar consumption is just as effective as advice from experts. The study's findings have been published in Frontiers in Nutrition.

Researchers from the HSE Center for Language and Brain took part in brain surgery on a patient who had been seriously wounded in the SMO. A shell fragment approximately five centimetres long entered through the eye socket, penetrated the cranial cavity, and became lodged in the brain, piercing the temporal lobe responsible for language. Surgeons at the Burdenko Main Military Clinical Hospital removed the foreign object while the patient remained conscious. During the operation, neurolinguists conducted language tests to ensure that language function was preserved.

An international team, including researchers from HSE University, examined an unusual SARS-CoV-2 sample obtained from an HIV-positive patient. Genetic analysis revealed multiple mutations and showed that the virus had been evolving inside the patient’s body for two years. This finding supports the theory that the virus can persist in individuals for years, gradually accumulate mutations, and eventually spill back into the population. The study's findings have been published in Frontiers in Cellular and Infection Microbiology.

Scientists at the HSE Centre for Language and Brain have demonstrated a more accurate way to identify the boundaries of language regions in the brain. They used magnetoencephalography (MEG) together with a sentence-completion task, which activates language areas and reveals their functioning in real time. This approach can help clinicians plan surgeries more effectively and improve diagnostic accuracy in cases where fMRI is not the optimal method. The study has been published in the European Journal of Neuroscience.

A team of researchers from Russia and the United Kingdom has, for the first time, provided a detailed account of the emergence and evolution of the Russian Sign Language (RSL) interpreter training system. This large-scale study spans from the 19^th century to the present day, revealing both the achievements and challenges faced by the professional community. Results have been published in The Routledge Handbook of Sign Language Translation and Interpreting.

Researchers at the HSE AI Research Centre have developed an AI model that opens up new possibilities for the diagnosis and treatment of serious diseases, including brain cancer and neurodegenerative disorders. Using artificial intelligence, the team studied G-quadruplexes—structures that play a crucial role in cellular function and in the development of organs and tissues. The findings have been published in Scientific Reports.